The executive, Brian Thompson, was shot in the chest in what people briefed on the investigations said appeared to be a targeted attack.

The chief executive of UnitedHealthcare was fatally shot in the chest in Midtown Manhattan on Wednesday morning, according to a police report and two people familiar with the matter.

The report said that the executive, Brian Thompson, 50, was shot just after 6:45 a.m. at 1335 Sixth Avenue, the address for the New York Hilton Midtown, according to the report. Mr. Thompson was taken to Mount Sinai West in critical condition.

Police officers are still searching for the gunman, who fled east on Sixth Avenue, the report said. He was wearing a cream-colored jacket, a black face mask and a gray backpack.

The police believe Mr. Thompson was targeted in the attack.

Mr. Thompson was promoted to chief executive of UnitedHealthcare in April 2021, heading one unit of the larger UnitedHealth Group. He lives in Minnesota.

UnitedHealth Group, which provides insurance and pharmacy benefits through several units, is one of the nation’s largest corporations. It reported $372 billion in revenues in 2023.

This is a breaking news story and will be updated.