Physical activity can brighten your outlook and calm your nerves — if you do it strategically.

We’ve all encountered that person who comes back from the gym or a run seemingly high on life. In fact, scientists say that even a single bout of exercise can alter your neurochemistry in ways that create feelings of hope, calm, connection and a generally better mood.

But for others, a workout just leaves them feeling worn out.

“It’s normal not to find exercise rewarding,” said Daniel Lieberman, an evolutionary biologist at Harvard University. “There’s nothing wrong with you.”

While some people are simply more genetically or psychologically inclined to enjoy exercise, recent discoveries have helped experts understand why it can be such a high. And, they say, by making a few changes to your workout, you can train your body and mind to find exercise more pleasurable.

Scientists once thought the rush people felt from exercise came exclusively from endorphins, which act like natural opioids in the brain by relieving pain. But in recent decades, researchers have discovered a more complex cocktail of other key “feel-good” chemicals produced during movement.

Each ingredient plays a distinct but complementary role, said Julia Basso, an assistant professor at Virginia Tech who runs a lab studying the effects of exercise on the brain. “These neurochemicals are really working in tandem,” she said.

The most potent players appear to be endocannabinoids, which share similar molecular structure with THC, and bind to the same receptors in the brain — giving you that buzzy feeling that all is right in the world.

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