{"id":7477,"date":"2024-06-10T09:00:35","date_gmt":"2024-06-10T09:00:35","guid":{"rendered":"http:\/\/medexperts.pro\/?p=7477"},"modified":"2024-06-10T09:23:29","modified_gmt":"2024-06-10T09:23:29","slug":"leqembi-and-alzheimers-what-to-know-about-the-new-drug-treatment-and-benefits","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=7477","title":{"rendered":"Leqembi and Alzheimer\u2019s: What to Know About the New Drug, Treatment and Benefits"},"content":{"rendered":"<div><\/div>\n<p id=\"article-summary\" class=\"css-79rysd e1wiw3jv0\">As the F.D.A. considers a new Alzheimer\u2019s medication, we asked experts how the rollout of a similar drug has gone.<\/p>\n<section class=\"meteredContent css-1r7ky0e\">\n<div class=\"css-s99gbd StoryBodyCompanionColumn\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Over the last three years, a new class of Alzheimer\u2019s drug, the first to treat a root cause of the disease, has set off a <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2021\/07\/19\/health\/alzheimers-drug-aduhelm-fda.html\" title>roller coaster<\/a> of hope and disappointment. But while these so-called anti-amyloid antibodies had a <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2024\/01\/31\/business\/biogen-alzheimers-aduhelm.html\" title>rough start<\/a>, many patients and their doctors are feeling more optimistic now that one of the medications is finally being used more widely.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Lecanemab (brand name Leqembi) was <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2023\/07\/06\/health\/alzheimers-leqembi-medicare.html\" title>given full approval<\/a> by the Food and Drug Administration in July 2023 and is currently the only one of its class available to Alzheimer\u2019s patients, outside clinical trials. The drug has been shown to slow the progression of the disease, but its benefits are fairly modest. It is also a burdensome therapy and has a high risk of troubling side effects.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">With lecanemab having been approved for nearly a year \u2014 and with a similar drug, <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2024\/03\/08\/health\/alzheimers-drug-donanemab.html\" title>donanemab<\/a>, being reviewed by an F.D.A. advisory committee at a meeting on Monday \u2014 The New York Times checked in with experts at three major medical centers about who\u2019s receiving lecanemab and how they\u2019re responding.<\/p>\n<h2 class=\"css-1u37br4 eoo0vm40\" id=\"link-6772a88a\">Who\u2019s being prescribed lecanemab?<\/h2>\n<p class=\"css-at9mc1 evys1bk0\">There are strict requirements for patients to be eligible for lecanemab; by <a class=\"css-yywogo\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37586881\/\" title rel=\"noopener noreferrer\" target=\"_blank\">one estimate<\/a>, fewer than 20 percent met the qualifications for the medication. Neurologists at the Mayo Clinic, Massachusetts General Hospital and the University of California, San Francisco, all described a similar review process when deciding which patients are good candidates.<\/p>\n<\/div>\n<\/div>\n<div><\/div>\n<div class=\"css-s99gbd StoryBodyCompanionColumn\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">First, the patient must be diagnosed with <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2024\/02\/06\/well\/mind\/mild-cognitive-impairment-diagnosis.html\" title>mild cognitive impairment<\/a> or mild dementia, the earliest two stages of Alzheimer\u2019s disease. Second, because <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2023\/07\/06\/health\/leqembi-alzheimers-drug.html\" title>lecanemab<\/a> works by removing the amyloid plaques that are a hallmark of the disease, patients undergo a PET scan or a lumbar puncture to make sure plaques are actually present in the brain. Third, the patient needs an M.R.I. to screen for signs of other brain diseases.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe want to make sure that they don\u2019t have another explanation for their cognitive problems,\u201d said Dr. Ronald Petersen, the director of the Mayo Clinic Alzheimer\u2019s Disease Research Center.<\/p>\n<div class=\"css-1336jj\">\n<div class=\"css-121kum4\">\n<div class=\"css-171d1bw\"><\/div>\n<div class=\"css-asuuk5\">\n<div class=\"css-7axq9l\" data-testid=\"optimistic-truncator-noscript\">\n<div data-testid=\"optimistic-truncator-noscript-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">We are having trouble retrieving the article content.<\/p>\n<p class=\"css-3kpklk\">Please enable JavaScript in your browser settings.<\/p>\n<\/div>\n<\/div>\n<div class=\"css-1dv1kvn\" id=\"optimistic-truncator-a11y\">\n<hr \/>\n<p>Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0<a href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F06%2F10%2Fwell%2Fmind%2Falzheimers-treatment-leqembi.html&amp;asset=opttrunc\">log into<\/a>\u00a0your Times account, or\u00a0<a href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F06%2F10%2Fwell%2Fmind%2Falzheimers-treatment-leqembi.html\">subscribe<\/a>\u00a0for all of The Times.<\/p>\n<hr \/>\n<\/div>\n<div class=\"css-1g71tqy\">\n<div data-testid=\"optimistic-truncator-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">Thank you for your patience while we verify access.<\/p>\n<p class=\"css-3kpklk\">Already a subscriber?\u00a0<a data-testid=\"log-in-link\" class=\"css-z5ryv4\" href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F06%2F10%2Fwell%2Fmind%2Falzheimers-treatment-leqembi.html&amp;asset=opttrunc\">Log in<\/a>.<\/p>\n<p class=\"css-3kpklk\">Want all of The Times?\u00a0<a data-testid=\"subscribe-link\" class=\"css-z5ryv4\" href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F06%2F10%2Fwell%2Fmind%2Falzheimers-treatment-leqembi.html\">Subscribe<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>As the F.D.A. considers a new Alzheimer\u2019s medication, we asked experts how the rollout of a similar drug has gone.Over the last three years, a new class of Alzheimer\u2019s drug, the first to treat a root cause of the disease, has set off a roller coaster of hope and disappointment. But while these so-called anti-amyloid antibodies had a rough start, many patients and their doctors are feeling more optimistic now that one of the medications is finally being used more widely.Lecanemab (brand name Leqembi) was given full approval by the Food and Drug Administration in July 2023 and is currently the only one of its class available to Alzheimer\u2019s patients, outside clinical trials. The drug has been shown to slow the progression of the disease, but its benefits are fairly modest. It is also a burdensome therapy and has a high risk of troubling side effects.With lecanemab having been approved for nearly a year \u2014 and with a similar drug, donanemab, being reviewed by an F.D.A. advisory committee at a meeting on Monday \u2014 The New York Times checked in with experts at three major medical centers about who\u2019s receiving lecanemab and how they\u2019re responding.Who\u2019s being prescribed lecanemab?There are strict requirements for patients to be eligible for lecanemab; by one estimate, fewer than 20 percent met the qualifications for the medication. Neurologists at the Mayo Clinic, Massachusetts General Hospital and the University of California, San Francisco, all described a similar review process when deciding which patients are good candidates.First, the patient must be diagnosed with mild cognitive impairment or mild dementia, the earliest two stages of Alzheimer\u2019s disease. Second, because lecanemab works by removing the amyloid plaques that are a hallmark of the disease, patients undergo a PET scan or a lumbar puncture to make sure plaques are actually present in the brain. Third, the patient needs an M.R.I. to screen for signs of other brain diseases.\u201cWe want to make sure that they don\u2019t have another explanation for their cognitive problems,\u201d said Dr. Ronald Petersen, the director of the Mayo Clinic Alzheimer\u2019s Disease Research Center.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0log into\u00a0your Times account, or\u00a0subscribe\u00a0for all of The Times.Thank you for your patience while we verify access.Already a subscriber?\u00a0Log in.Want all of The Times?\u00a0Subscribe.<\/p>\n","protected":false},"author":1,"featured_media":7479,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-7477","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/7477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7477"}],"version-history":[{"count":2,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/7477\/revisions"}],"predecessor-version":[{"id":7480,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/7477\/revisions\/7480"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/7479"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}