{"id":35180,"date":"2025-09-24T11:05:10","date_gmt":"2025-09-24T11:05:10","guid":{"rendered":"https:\/\/medexperts.pro\/?p=35180"},"modified":"2025-09-24T11:23:26","modified_gmt":"2025-09-24T11:23:26","slug":"huntingtons-disease-successfully-treated-for-first-time","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=35180","title":{"rendered":"Huntington&#8217;s disease successfully treated for first time"},"content":{"rendered":"<div data-component=\"byline-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<div data-testid=\"byline-new\" class=\"sc-c4820dd1-0 cYDsPh\">\n<div class=\"sc-c4820dd1-1 jZKXfd\">17 minutes ago<\/p>\n<p><button disabled type=\"button\" aria-label=\"Share\" class=\"sc-28fdc07f-2 sc-28fdc07f-5 sc-28fdc07f-6 dlYDVt diMtqv hnXVJa\"><span data-testid=\"button-icon-wrapper\" class=\"sc-28fdc07f-0 Fzgas\"><\/span><span data-testid=\"button-text\" aria-hidden=\"false\" class=\"sc-28fdc07f-1 jjqoAk\">Share<\/span><\/button><button disabled type=\"button\" aria-label=\"Save\" data-action=\"save\" class=\"sc-28fdc07f-2 sc-28fdc07f-5 sc-28fdc07f-6 hyMuGj gQfYWA jZyXEp\"><span data-testid=\"button-icon-wrapper\" class=\"sc-28fdc07f-0 Fzgas\"><\/span><span data-testid=\"button-text\" aria-hidden=\"false\" class=\"sc-28fdc07f-1 jjqoAk\">Save<\/span><\/button><\/p>\n<\/div>\n<p><span data-testid=\"byline-new-contributors\" class=\"sc-c4820dd1-11 bxdaHR\"><\/p>\n<p><span class=\"sc-c4820dd1-7 dbQBRo\">James Gallagher<\/span><span data-testid=\"undefined-role-location\" class=\"sc-c4820dd1-8 evcqcz\">Health and science correspondent<\/span><\/p>\n<p><\/span><\/p>\n<p><button disabled type=\"button\" aria-label=\"Share\" class=\"sc-28fdc07f-2 sc-28fdc07f-5 sc-28fdc07f-6 dlYDVt diMtqv hnXVJa\"><span data-testid=\"button-icon-wrapper\" class=\"sc-28fdc07f-0 Fzgas\"><\/span><span data-testid=\"button-text\" aria-hidden=\"false\" class=\"sc-28fdc07f-1 jjqoAk\">Share<\/span><\/button><button disabled type=\"button\" aria-label=\"Save\" data-action=\"save\" class=\"sc-28fdc07f-2 sc-28fdc07f-5 sc-28fdc07f-6 hyMuGj gQfYWA jZyXEp\"><span data-testid=\"button-icon-wrapper\" class=\"sc-28fdc07f-0 Fzgas\"><\/span><span data-testid=\"button-text\" aria-hidden=\"false\" class=\"sc-28fdc07f-1 jjqoAk\">Save<\/span><\/button><\/p>\n<\/div>\n<\/div>\n<figure>\n<div data-component=\"image-block\" class=\"sc-3b6b161a-0 kSquvq\">\n<div data-testid=\"hero-image\" class=\"sc-86c96223-1 evkFpM\"><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/66dcf740-98c2-11f0-94c0-d393b11c46d7.jpg.webp\" loading=\"eager\" alt=\"BBC\/Fergus Walsh Two scientists, Professors Ed Wild and Sarah Tabrizi, are pictured from the shoulders up. They are both smiling and wearing white lab coats. Prof Wild on the left has a tightly cropped beard. Prof Tabrizi on the right has long wavy hair. They are clearly in a laboratory with scientific equipment on shelves in the background.\" class=\"sc-86c96223-0 fHZDyi\" \/><span class=\"sc-86c96223-2 hqrvRC\">BBC\/Fergus Walsh<\/span><\/div>\n<\/div>\n<\/figure>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">One of the cruellest and most devastating diseases \u2013 Huntington&#8217;s \u2013 has been successfully treated for the first time, say doctors.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The disease runs through families, relentlessly kills brain cells and resembles a combination of dementia, Parkinson&#8217;s and motor neurone disease.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of &#8220;good quality life&#8221;, Prof Sarah Tabrizi told BBC News.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The new treatment is a type of gene therapy given during 12 to 18 hours of delicate brain surgery.<\/p>\n<\/div>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">The first symptoms of Huntington&#8217;s disease tend to appear in your 30s or 40s and is normally fatal within two decades \u2013 opening the possibility that earlier treatment could prevent symptoms from ever emerging.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Prof Tabrizi, director of the University College London Huntington&#8217;s Disease Centre, described the results as &#8220;spectacular&#8221;. <\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">&#8220;We never in our wildest dreams would have expected a 75% slowing of clinical progression,&#8221; she said.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families.<\/p>\n<\/div>\n<figure>\n<div data-component=\"image-block\" class=\"sc-3b6b161a-0 jHorPx\">\n<div data-testid=\"image\" class=\"sc-86c96223-1 evkFpM\"><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/grey-placeholder.png\" class=\"sc-86c96223-0 iMuqLZ hide-when-no-script\" aria-label=\"image unavailable\" \/><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/978792c0-98c1-11f0-94c0-d393b11c46d7.jpg.webp\" loading=\"lazy\" alt=\"BBC\/Fergus Walsh Jack May-Davis is smiling and is wearing a pale blue shirt. He is standing on a street with green hedges and a row of cars blurred in the background\" class=\"sc-86c96223-0 fHZDyi\" \/><span class=\"sc-86c96223-2 hqrvRC\">BBC\/Fergus Walsh<\/span><\/div>\n<\/div>\n<\/figure>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">Huntington&#8217;s runs through Jack May-Davis&#8217; family. He has the faulty gene that causes the disease, as did his dad, Fred, and his grandmother, Joyce.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Jack said it was &#8220;really awful and horrible&#8221; watching his dad&#8217;s inexorable decline. <\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The first symptoms appeared in Fred&#8217;s late 30s, including changes in behaviour and the way he moved. He eventually needed 24\/7 palliative care before he died at the age of 54, in 2016.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Jack is 30, a barrister&#8217;s clerk, newly engaged to Chloe and has taken part in research at UCL to turn his diagnosis into a positive.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">But he&#8217;d always known he was destined to share his father&#8217;s fate, until today.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Now he says the &#8220;absolutely incredible&#8221; breakthrough has left him &#8220;overwhelmed&#8221; and able to look to a future that &#8220;seems a little bit brighter, it does allow me to think my life could be that much longer&#8221;.<\/p>\n<\/div>\n<figure>\n<div data-component=\"image-block\" class=\"sc-3b6b161a-0 jHorPx\">\n<div data-testid=\"image\" class=\"sc-86c96223-1 evkFpM\"><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/grey-placeholder.png\" class=\"sc-86c96223-0 iMuqLZ hide-when-no-script\" aria-label=\"image unavailable\" \/><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/bc1a0c00-9937-11f0-928c-71dbb8619e94.jpg.webp\" loading=\"lazy\" alt=\"May-Davis family An old family photograph of Fred resting his head on his hand with a young Jack in his lap\" class=\"sc-86c96223-0 fHZDyi\" \/><span class=\"sc-86c96223-2 hqrvRC\">May-Davis family<\/span><\/div>\n<\/div>\n<\/figure>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">Huntington&#8217;s disease is caused by an error in part of our DNA called the huntingtin gene.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">This mutation turns a normal protein needed in the brain \u2013 called the huntingtin protein \u2013 into a killer of neurons.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The goal of the treatment is to reduce levels of this toxic protein permanently, in a single dose.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The therapy uses cutting edge genetic medicine combining gene therapy and gene silencing technologies.<\/p>\n<\/div>\n<figure>\n<div data-component=\"image-block\" class=\"sc-3b6b161a-0 geRyoc\">\n<div data-testid=\"image\" class=\"sc-86c96223-1 evkFpM\"><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/grey-placeholder.png\" class=\"sc-86c96223-0 iMuqLZ hide-when-no-script\" aria-label=\"image unavailable\" \/><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/0ca1b1e0-98a3-11f0-928c-71dbb8619e94.png.webp\" loading=\"lazy\" alt=\"Graphical illustration of how the therapy works separated into four tiles. The first shows a spindly brain cell with a zoomed-in section showing a DNA double helix in blue with a red section denoting the mutated DNA and the build up of toxic protein, also red, inside the brain cell. Tile 2 shows two neurons and hexagonal viruses with a purple line in the middle. Tile 3 shows a close-up of the neurons from before with the viruses inside and releasing their purple squiggly line. Tile 4 goes back to the same zoomed-in view of a neuron, but this time the purple squiggles are sticking to the previous genetic code so there is less toxic protein being made, represented by it being shaded out. \" class=\"sc-86c96223-0 fHZDyi\" \/><\/div>\n<\/div>\n<\/figure>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">It starts with a safe virus that has been altered to contain a specially designed sequence of DNA.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions &#8211; the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The virus then acts like a microscopic postman \u2013 delivering the new piece of DNA inside brain cells, where it becomes active.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">This turns the neurons into a factory for making the therapy to avert their own death.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells&#8217; DNA for building mutant huntingtin.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">This results in lower levels of mutant huntingtin in the brain.<\/p>\n<\/div>\n<figure>\n<div data-component=\"image-block\" class=\"sc-3b6b161a-0 jHorPx\">\n<div data-testid=\"image\" class=\"sc-86c96223-1 evkFpM\"><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/grey-placeholder.png\" class=\"sc-86c96223-0 iMuqLZ hide-when-no-script\" aria-label=\"image unavailable\" \/><img decoding=\"async\" src=\"https:\/\/medexperts.pro\/wp-content\/uploads\/2025\/09\/0823bd50-98c3-11f0-94c0-d393b11c46d7.png.webp\" loading=\"lazy\" alt=\"UCLH The images show two cross sections of the human brain in black and white side- by-side. You can see the semi-circular outline of the skull. Inside is the folded brain matter. The key difference between the two images is the greater amount of dark space on the right demonstrating where brain tissue has died.\" class=\"sc-86c96223-0 fHZDyi\" \/><span class=\"sc-86c96223-2 hqrvRC\">UCLH<\/span><\/div>\n<\/div>\n<\/figure>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">Results from the trial &#8211; which involved 29 patients &#8211; have been released in a statement by the company uniQure, but have not yet been published in full for review by other specialists.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid \u2013 a clear sign of brain cells dying \u2013 should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">&#8220;This is the result we&#8217;ve been waiting for,&#8221; said Prof Ed Wild, consultant neurologist at the National Hospital for Neurology and Neurosurgery at UCLH.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">&#8220;There was every chance that we would never see a result like this, so to be living in a world where we know this is not only possible, but the actual magnitude of the effect is breathtaking, it&#8217;s very difficult to fully encapsulate the emotion.&#8221;<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">He said he was &#8220;a bit teary&#8221; thinking about the impact it could have on families.<\/p>\n<\/div>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">The treatment was considered safe, although some patients did develop inflammation from the virus that caused headaches and confusion that either resolved or needed steroid treatment.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Prof Wild anticipates the therapy &#8220;should last for life&#8221; because brain cells are not replaced by the body in the same manner as blood, bone and skin are constantly renewed.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Approximately 75,000 people have Huntington&#8217;s disease in the UK, US and Europe with hundreds of thousands carrying the mutation meaning they will develop the disease.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">UniQure says it will apply for a licence in the US in the first quarter of 2026 with the aim of launching the drug later that year. Conversations with authorities in the UK and Europe will start next year, but the initial focus is on the US.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">Dr Walid Abi-Saab, the chief medical officer at uniQure, said he was &#8220;incredibly excited&#8221; about what the results mean for families, and added that the treatment had &#8220;the potential to fundamentally transform&#8221; Huntington&#8217;s disease.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">However, the drug will not be available for everyone due to the highly complex surgery and the anticipated cost.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">&#8220;It will be expensive for sure,&#8221; says Prof Wild.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">There isn&#8217;t an official price for the drug. Gene therapies are often pricey, but their long-term impact means that can still be affordable. In the UK, the NHS does pay for a \u00a32.6m-per-patient gene therapy for haemophilia B.<\/p>\n<\/div>\n<div data-component=\"text-block\" class=\"sc-3b6b161a-0 jdlrvG\">\n<p class=\"sc-9a00e533-0 bJoRPJ\">Prof Tabrizi says this gene therapy &#8220;is the beginning&#8221; and will open the gates for therapies that can reach more people.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">She paid tribute to the &#8220;truly brave&#8221; volunteers who took part in the trial, saying she was &#8220;overjoyed for the patients and families&#8221;.<\/p>\n<p class=\"sc-9a00e533-0 bJoRPJ\">She is already working with a group of young people who know they have the gene, but don&#8217;t yet have symptoms \u2013 known as stage zero Huntington&#8217;s \u2013 and is aiming to do the first prevention trial to see if the disease can be significantly delayed or even stopped completely.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>17 minutes agoShareSaveJames GallagherHealth and science correspondentShareSaveBBC\/Fergus WalshOne of the cruellest and most devastating diseases \u2013 Huntington&#8217;s \u2013 has been successfully treated for the first time, say doctors.The disease runs through families, relentlessly kills brain cells and resembles a combination of dementia, Parkinson&#8217;s and motor neurone disease.An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients.It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of &#8220;good quality life&#8221;, Prof Sarah Tabrizi told BBC News.The new treatment is a type of gene therapy given during 12 to 18 hours of delicate brain surgery.The first symptoms of Huntington&#8217;s disease tend to appear in your 30s or 40s and is normally fatal within two decades \u2013 opening the possibility that earlier treatment could prevent symptoms from ever emerging.Prof Tabrizi, director of the University College London Huntington&#8217;s Disease Centre, described the results as &#8220;spectacular&#8221;. &#8220;We never in our wildest dreams would have expected a 75% slowing of clinical progression,&#8221; she said.None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair.Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families.BBC\/Fergus WalshHuntington&#8217;s runs through Jack May-Davis&#8217; family. He has the faulty gene that causes the disease, as did his dad, Fred, and his grandmother, Joyce.Jack said it was &#8220;really awful and horrible&#8221; watching his dad&#8217;s inexorable decline. The first symptoms appeared in Fred&#8217;s late 30s, including changes in behaviour and the way he moved. He eventually needed 24\/7 palliative care before he died at the age of 54, in 2016.Jack is 30, a barrister&#8217;s clerk, newly engaged to Chloe and has taken part in research at UCL to turn his diagnosis into a positive.But he&#8217;d always known he was destined to share his father&#8217;s fate, until today.Now he says the &#8220;absolutely incredible&#8221; breakthrough has left him &#8220;overwhelmed&#8221; and able to look to a future that &#8220;seems a little bit brighter, it does allow me to think my life could be that much longer&#8221;.May-Davis familyHuntington&#8217;s disease is caused by an error in part of our DNA called the huntingtin gene.This mutation turns a normal protein needed in the brain \u2013 called the huntingtin protein \u2013 into a killer of neurons.The goal of the treatment is to reduce levels of this toxic protein permanently, in a single dose.The therapy uses cutting edge genetic medicine combining gene therapy and gene silencing technologies.It starts with a safe virus that has been altered to contain a specially designed sequence of DNA.This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions &#8211; the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery.The virus then acts like a microscopic postman \u2013 delivering the new piece of DNA inside brain cells, where it becomes active.This turns the neurons into a factory for making the therapy to avert their own death.The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells&#8217; DNA for building mutant huntingtin.This results in lower levels of mutant huntingtin in the brain.UCLHResults from the trial &#8211; which involved 29 patients &#8211; have been released in a statement by the company uniQure, but have not yet been published in full for review by other specialists.The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life.The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid \u2013 a clear sign of brain cells dying \u2013 should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.&#8221;This is the result we&#8217;ve been waiting for,&#8221; said Prof Ed Wild, consultant neurologist at the National Hospital for Neurology and Neurosurgery at UCLH.&#8221;There was every chance that we would never see a result like this, so to be living in a world where we know this is not only possible, but the actual magnitude of the effect is breathtaking, it&#8217;s very difficult to fully encapsulate the emotion.&#8221;He said he was &#8220;a bit teary&#8221; thinking about the impact it could have on families.The treatment was considered safe, although some patients did develop inflammation from the virus that caused headaches and confusion that either resolved or needed steroid treatment.Prof Wild anticipates the therapy &#8220;should last for life&#8221; because brain cells are not replaced by the body in the same manner as blood, bone and skin are constantly renewed.Approximately 75,000 people have Huntington&#8217;s disease in the UK, US and Europe with hundreds of thousands carrying the mutation meaning they will develop the disease.UniQure says it will apply for a licence in the US in the first quarter of 2026 with the aim of launching the drug later that year. Conversations with authorities in the UK and Europe will start next year, but the initial focus is on the US.Dr Walid Abi-Saab, the chief medical officer at uniQure, said he was &#8220;incredibly excited&#8221; about what the results mean for families, and added that the treatment had &#8220;the potential to fundamentally transform&#8221; Huntington&#8217;s disease.However, the drug will not be available for everyone due to the highly complex surgery and the anticipated cost.&#8221;It will be expensive for sure,&#8221; says Prof Wild.There isn&#8217;t an official price for the drug. Gene therapies are often pricey, but their long-term impact means that can still be affordable. In the UK, the NHS does pay for a \u00a32.6m-per-patient gene therapy for haemophilia B.Prof Tabrizi says this gene therapy &#8220;is the beginning&#8221; and will open the gates for therapies that can reach more people.She paid tribute to the &#8220;truly brave&#8221; volunteers who took part in the trial, saying she was &#8220;overjoyed for the patients and families&#8221;.She is already working with a group of young people who know they have the gene, but don&#8217;t yet have symptoms \u2013 known as stage zero Huntington&#8217;s \u2013 and is aiming to do the first prevention trial to see if the disease can be significantly delayed or even stopped completely.<\/p>\n","protected":false},"author":1,"featured_media":34940,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33],"tags":[],"class_list":["post-35180","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/35180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35180"}],"version-history":[{"count":3,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/35180\/revisions"}],"predecessor-version":[{"id":35188,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/35180\/revisions\/35188"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/34940"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}