{"id":24994,"date":"2025-03-30T18:30:06","date_gmt":"2025-03-30T18:30:06","guid":{"rendered":"http:\/\/medexperts.pro\/?p=24994"},"modified":"2025-03-30T19:30:35","modified_gmt":"2025-03-30T19:30:35","slug":"eli-lilly-drug-reduces-mysterious-lpa-particle-involved-in-heart-attack-risk","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=24994","title":{"rendered":"Eli Lilly Drug Reduces Mysterious Lp(a) Particle Involved in Heart Attack Risk"},"content":{"rendered":"
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The Eli Lilly drug caused a major drop in the blood levels of Lp(a), but further research is needed to show that it will prevent heart attacks and strokes.<\/p>\n

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As many as one in five people \u2014 an estimated 64 million in the United States \u2014 have elevated levels of a tiny particle in their blood. It can greatly increase the risk of heart attacks and strokes.<\/p>\n

But few know about it, and almost no doctors test for it, because there was not much to be done. Diet does not help. Neither does exercise. There have been no drugs.<\/p>\n

But in the near future, that may change.<\/p>\n

On Sunday, cardiologists announced that an experimental drug made by Eli Lilly, lepodisiran, could lower levels of the particle, Lp(a), by 94 percent with a single injection. The effects lasted for six months and there were no significant side effects.<\/p>\n

But it is not yet confirmed that reducing Lp(a) levels also reduces the risk of heart attacks and strokes. That awaits large clinical trials that are now underway.<\/p>\n<\/div>\n<\/div>\n

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The Lilly research was presented Sunday at the annual meeting of the American College of Cardiology and simultaneously published<\/a> in the New England Journal of Medicine. At least four other companies are also testing innovative drugs that block the body\u2019s production of Lp(a), a mix of lipids and a protein.<\/p>\n

Dr. David Maron, a preventive cardiologist at Stanford not involved in the Lilly research, said the evidence of profound and long-lasting reduction in lipoprotein levels with lepodisiran was \u201cthrilling.\u201d<\/p>\n

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The Eli Lilly drug caused a major drop in the blood levels of Lp(a), but further research is needed to show that it will prevent heart attacks and strokes.As many as one in five people \u2014 an estimated 64 million in the United States \u2014 have elevated levels of a tiny particle in their blood. It can greatly increase the risk of heart attacks and strokes.But few know about it, and almost no doctors test for it, because there was not much to be done. Diet does not help. Neither does exercise. There have been no drugs.But in the near future, that may change.On Sunday, cardiologists announced that an experimental drug made by Eli Lilly, lepodisiran, could lower levels of the particle, Lp(a), by 94 percent with a single injection. The effects lasted for six months and there were no significant side effects.But it is not yet confirmed that reducing Lp(a) levels also reduces the risk of heart attacks and strokes. That awaits large clinical trials that are now underway.The Lilly research was presented Sunday at the annual meeting of the American College of Cardiology and simultaneously published in the New England Journal of Medicine. At least four other companies are also testing innovative drugs that block the body\u2019s production of Lp(a), a mix of lipids and a protein.Dr. David Maron, a preventive cardiologist at Stanford not involved in the Lilly research, said the evidence of profound and long-lasting reduction in lipoprotein levels with lepodisiran was \u201cthrilling.\u201dWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0log into\u00a0your Times account, or\u00a0subscribe\u00a0for all of The Times.Thank you for your patience while we verify access.Already a subscriber?\u00a0Log in.Want all of The Times?\u00a0Subscribe.<\/p>\n","protected":false},"author":1,"featured_media":24996,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-24994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/24994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24994"}],"version-history":[{"count":2,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/24994\/revisions"}],"predecessor-version":[{"id":24997,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/24994\/revisions\/24997"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/24996"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}