{"id":21558,"date":"2025-02-04T23:22:48","date_gmt":"2025-02-05T00:22:48","guid":{"rendered":"http:\/\/medexperts.pro\/?p=21558"},"modified":"2025-02-05T00:30:34","modified_gmt":"2025-02-05T00:30:34","slug":"ozempic-like-drug-failed-to-treat-parkinsons-disease-in-trial","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=21558","title":{"rendered":"Ozempic-Like Drug Failed to Treat Parkinson\u2019s Disease in Trial"},"content":{"rendered":"
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The study may suggest that other researchers should be less optimistic about the prospects for treating a range of other conditions with newer weight-loss drugs.<\/p>\n

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The idea was so tantalizing. Drugs in the GLP-1 class, which includes Wegovy and Ozempic, have proved miraculous in treating weight loss<\/a> and other diseases<\/a>. And some researchers hoped that the drugs could also help with some of the most difficult diseases to treat \u2014 those of the brain, like Parkinson\u2019s.<\/p>\n

But now, at least for Parkinson\u2019s, that hope seems dimmed. A rigorous study that randomly assigned Parkinson\u2019s patients to take exenatide, a relative of Ozempic, showed absolutely no benefit or slowing of the course of the degenerative disease after 96 weeks.<\/p>\n

And there were no effect on patient symptoms, no effect on brain scans, no subgroup that showed any benefit. No matter how the researchers sliced the data the results were the same.<\/p>\n

The study<\/a>, published Tuesday in The Lancet, is bad news for the half million Americans who have been diagnosed with Parkinson\u2019s disease. Symptoms include tremors, stiffness and difficulty with balance. Patients also may develop dementia. Treatments, including medications and deep brain stimulation, can help with symptoms. But no treatment has been shown to slow the disease\u2019s progress.<\/p>\n<\/div>\n<\/div>\n

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\u201cIt\u2019s hugely disappointing,\u201d said Dr. Thomas Foltynie of University College London, who led the trial. \u201cWe were expecting we would come through and we would get a positive result.\u201d<\/p>\n

Parkinson\u2019s experts shared his sentiment.<\/p>\n

\u201cThis is a sobering moment,\u201d said Dr. Michael S. Okun, a Parkinson\u2019s disease expert at the University of Florida and the national medical adviser for the Parkinson\u2019s Foundation. \u201cThis is a really well done study and it came up empty-handed.\u201d<\/p>\n

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The study may suggest that other researchers should be less optimistic about the prospects for treating a range of other conditions with newer weight-loss drugs.The idea was so tantalizing. Drugs in the GLP-1 class, which includes Wegovy and Ozempic, have proved miraculous in treating weight loss and other diseases. And some researchers hoped that the drugs could also help with some of the most difficult diseases to treat \u2014 those of the brain, like Parkinson\u2019s.But now, at least for Parkinson\u2019s, that hope seems dimmed. A rigorous study that randomly assigned Parkinson\u2019s patients to take exenatide, a relative of Ozempic, showed absolutely no benefit or slowing of the course of the degenerative disease after 96 weeks.And there were no effect on patient symptoms, no effect on brain scans, no subgroup that showed any benefit. No matter how the researchers sliced the data the results were the same.The study, published Tuesday in The Lancet, is bad news for the half million Americans who have been diagnosed with Parkinson\u2019s disease. Symptoms include tremors, stiffness and difficulty with balance. Patients also may develop dementia. Treatments, including medications and deep brain stimulation, can help with symptoms. But no treatment has been shown to slow the disease\u2019s progress.\u201cIt\u2019s hugely disappointing,\u201d said Dr. Thomas Foltynie of University College London, who led the trial. \u201cWe were expecting we would come through and we would get a positive result.\u201dParkinson\u2019s experts shared his sentiment.\u201cThis is a sobering moment,\u201d said Dr. Michael S. Okun, a Parkinson\u2019s disease expert at the University of Florida and the national medical adviser for the Parkinson\u2019s Foundation. \u201cThis is a really well done study and it came up empty-handed.\u201dWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0log into\u00a0your Times account, or\u00a0subscribe\u00a0for all of The Times.Thank you for your patience while we verify access.Already a subscriber?\u00a0Log in.Want all of The Times?\u00a0Subscribe.<\/p>\n","protected":false},"author":1,"featured_media":21560,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-21558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/21558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21558"}],"version-history":[{"count":2,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/21558\/revisions"}],"predecessor-version":[{"id":21561,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/21558\/revisions\/21561"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/21560"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}