{"id":21276,"date":"2025-01-31T09:00:33","date_gmt":"2025-01-31T10:00:33","guid":{"rendered":"http:\/\/medexperts.pro\/?p=21276"},"modified":"2025-01-31T10:33:58","modified_gmt":"2025-01-31T10:33:58","slug":"could-ozempic-protect-against-alzheimers","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=21276","title":{"rendered":"Could Ozempic Protect Against Alzheimer\u2019s?"},"content":{"rendered":"<div><\/div>\n<p id=\"article-summary\" class=\"css-79rysd e1wiw3jv0\">Could a diabetes and weight loss drug benefit the brain? Here\u2019s what scientists are learning.<\/p>\n<section class=\"meteredContent css-1r7ky0e\">\n<div class=\"css-s99gbd StoryBodyCompanionColumn\" data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Over a decade ago, a <a class=\"css-yywogo\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21525299\/\" title rel=\"noopener noreferrer\" target=\"_blank\">smattering<\/a> of <a class=\"css-yywogo\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23973293\/\" title rel=\"noopener noreferrer\" target=\"_blank\">studies<\/a> suggested that early cousins of drugs like Ozempic and Mounjaro could prevent, or even reverse, signs of Alzheimer\u2019s disease in mice. Now, as the next generation of these medications has soared in popularity, and scientists discover they may have <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2024\/06\/21\/well\/sleep-apnea-weight-loss-drug.html\" title>wide-ranging<\/a> <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/interactive\/2023\/12\/20\/well\/live\/ozempic-weight-loss-drugs-diseases.html\" title>health benefits,<\/a> research is revving up to investigate whether the drugs that upended diabetes and obesity care could also revolutionize Alzheimer\u2019s treatment.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Emerging evidence seems encouraging \u2014 but questions and caveats abound.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cI think they\u2019re definitely promising,\u201d said Karolina Skibicka, a neuroscientist and the chair in metabolic physiology at Pennsylvania State University. \u201cAnd that\u2019s sort of how far I would go with the currently available evidence.\u201d<\/p>\n<h2 class=\"css-1u37br4 eoo0vm40\" id=\"link-15a16f70\">The Early Findings<\/h2>\n<p class=\"css-at9mc1 evys1bk0\">Research in rodents <a class=\"css-yywogo\" href=\"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-240730?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\" title rel=\"noopener noreferrer\" target=\"_blank\">has largely shown<\/a> that these types of diabetes and obesity drugs, which mimic metabolic hormones, can improve several hallmarks of Alzheimer\u2019s disease in the brain, as well as boost the animals\u2019 ability to learn and remember. However, there is a long history of all sorts of drugs treating Alzheimer\u2019s in mice but not providing the same benefits for humans.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">There are only a few studies so far examining whether these medications can reduce the risk for dementia in people.<\/p>\n<\/div>\n<\/div>\n<div data-testid=\"Dropzone-1\"><\/div>\n<div class=\"css-s99gbd StoryBodyCompanionColumn\" data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\"><a class=\"css-yywogo\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14313\" title rel=\"noopener noreferrer\" target=\"_blank\">One recent analysis<\/a> found that, over the course of three years, people taking semaglutide (the compound in Ozempic and the weight loss drug Wegovy) were about 40 to 70 percent less likely to be diagnosed with Alzheimer\u2019s disease compared with people on other diabetes medications.<\/p>\n<p class=\"css-at9mc1 evys1bk0\"><a class=\"css-yywogo\" href=\"https:\/\/www.nature.com\/articles\/s41591-024-03412-w\" title rel=\"noopener noreferrer\" target=\"_blank\">A paper<\/a> published this month reviewing a Veterans Affairs database similarly found that people prescribed these drugs were less likely to develop dementia compared with those who took other diabetes drugs. The benefit was more modest, though, with a roughly 10 percent decreased risk.<\/p>\n<div class=\"css-1336jj\">\n<div class=\"css-121kum4\">\n<div class=\"css-171quhb\"><\/div>\n<div class=\"css-asuuk5\">\n<div class=\"css-7axq9l\" data-testid=\"optimistic-truncator-noscript\">\n<div data-testid=\"optimistic-truncator-noscript-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">We are having trouble retrieving the article content.<\/p>\n<p class=\"css-3kpklk\">Please enable JavaScript in your browser settings.<\/p>\n<\/div>\n<\/div>\n<div class=\"css-1dv1kvn\" id=\"optimistic-truncator-a11y\">\n<hr \/>\n<p>Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0<a href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2025%2F01%2F31%2Fwell%2Fmind%2Fozempic-alzheimers.html&amp;asset=opttrunc\">log into<\/a>\u00a0your Times account, or\u00a0<a href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2025%2F01%2F31%2Fwell%2Fmind%2Fozempic-alzheimers.html\">subscribe<\/a>\u00a0for all of The Times.<\/p>\n<hr \/>\n<\/div>\n<div class=\"css-1g71tqy\">\n<div data-testid=\"optimistic-truncator-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">Thank you for your patience while we verify access.<\/p>\n<p class=\"css-3kpklk\">Already a subscriber?\u00a0<a data-testid=\"log-in-link\" class=\"css-z5ryv4\" href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2025%2F01%2F31%2Fwell%2Fmind%2Fozempic-alzheimers.html&amp;asset=opttrunc\">Log in<\/a>.<\/p>\n<p class=\"css-3kpklk\">Want all of The Times?\u00a0<a data-testid=\"subscribe-link\" class=\"css-z5ryv4\" href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2025%2F01%2F31%2Fwell%2Fmind%2Fozempic-alzheimers.html\">Subscribe<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Could a diabetes and weight loss drug benefit the brain? Here\u2019s what scientists are learning.Over a decade ago, a smattering of studies suggested that early cousins of drugs like Ozempic and Mounjaro could prevent, or even reverse, signs of Alzheimer\u2019s disease in mice. Now, as the next generation of these medications has soared in popularity, and scientists discover they may have wide-ranging health benefits, research is revving up to investigate whether the drugs that upended diabetes and obesity care could also revolutionize Alzheimer\u2019s treatment.Emerging evidence seems encouraging \u2014 but questions and caveats abound.\u201cI think they\u2019re definitely promising,\u201d said Karolina Skibicka, a neuroscientist and the chair in metabolic physiology at Pennsylvania State University. \u201cAnd that\u2019s sort of how far I would go with the currently available evidence.\u201dThe Early FindingsResearch in rodents has largely shown that these types of diabetes and obesity drugs, which mimic metabolic hormones, can improve several hallmarks of Alzheimer\u2019s disease in the brain, as well as boost the animals\u2019 ability to learn and remember. However, there is a long history of all sorts of drugs treating Alzheimer\u2019s in mice but not providing the same benefits for humans.There are only a few studies so far examining whether these medications can reduce the risk for dementia in people.One recent analysis found that, over the course of three years, people taking semaglutide (the compound in Ozempic and the weight loss drug Wegovy) were about 40 to 70 percent less likely to be diagnosed with Alzheimer\u2019s disease compared with people on other diabetes medications.A paper published this month reviewing a Veterans Affairs database similarly found that people prescribed these drugs were less likely to develop dementia compared with those who took other diabetes drugs. The benefit was more modest, though, with a roughly 10 percent decreased risk.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0log into\u00a0your Times account, or\u00a0subscribe\u00a0for all of The Times.Thank you for your patience while we verify access.Already a subscriber?\u00a0Log in.Want all of The Times?\u00a0Subscribe.<\/p>\n","protected":false},"author":1,"featured_media":21278,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-21276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/21276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21276"}],"version-history":[{"count":2,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/21276\/revisions"}],"predecessor-version":[{"id":21279,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/21276\/revisions\/21279"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/21278"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}