{"id":16182,"date":"2024-11-08T09:03:16","date_gmt":"2024-11-08T10:03:16","guid":{"rendered":"https:\/\/medexperts.pro\/?p=16182"},"modified":"2024-11-08T10:25:09","modified_gmt":"2024-11-08T10:25:09","slug":"richard-pazdur-fda-cancer-chief-discusses-25-years-of-innovation","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=16182","title":{"rendered":"Richard Pazdur, FDA Cancer Chief, Discusses 25 Years of Innovation"},"content":{"rendered":"
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Twenty five years ago, cancer was almost a different disease. Despite the so-called War on Cancer, declared in 1971 by President Richard Nixon, treatments had mostly remained the same blunt instruments \u2014 brutal chemotherapy, surgery and radiation. It seemed as if cancer had won the war.<\/p>\n

Now, cancer medicine is in a new place. An increasing array of treatments precisely target the cancer itself. And for some cancers, researchers have learned to direct the immune system to kill the malignant cells. Cures are possible for some cancers that had seemed incurable. Many patients can live longer and better lives than ever seemed possible. Cancer death rates have been plunging, and researchers attribute most of that to improved treatments.<\/p>\n

Overseeing this change at the Food and Drug Administration has been Dr. Richard Pazdur, currently the director of the Oncology Center of Excellence. Trained as an oncologist, he leads the agency and its cancer specialists in determining how cancer drugs are tested and approved.<\/p>\n

Through 25 years at the agency in a variety of roles, he has been present from the start of the new era and has seen firsthand how scientific discoveries completely changed the prospects for many cancer patients. In two edited and condensed conversations, he discussed what he has seen, and what he hopes for.<\/p>\n<\/div>\n<\/div>\n

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What was it like to be a cancer doctor when you first began, and what has changed?<\/strong><\/p>\n

When I started in medical oncology in 1979, we had less than 40 oncology drugs for all cancers. I came to the F.D.A. in 1999, thinking that most drug development would be done by the National Cancer Institute. I thought industry would have very little interest because most drugs were short course with excessive toxicity and many patients had a poor prognosis.<\/p>\n

I couldn\u2019t have been more wrong. For many patients, things have changed dramatically. From 1999 until the present, <\/em>we approved 201 cancer drugs. When I came to the F.D.A. there were about 10 medical oncologists at the agency. Now there are 100.<\/p>\n

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Twenty five years ago, cancer was almost a different disease. Despite the so-called War on Cancer, declared in 1971 by President Richard Nixon, treatments had mostly remained the same blunt instruments \u2014 brutal chemotherapy, surgery and radiation. It seemed as if cancer had won the war.Now, cancer medicine is in a new place. An increasing array of treatments precisely target the cancer itself. And for some cancers, researchers have learned to direct the immune system to kill the malignant cells. Cures are possible for some cancers that had seemed incurable. Many patients can live longer and better lives than ever seemed possible. Cancer death rates have been plunging, and researchers attribute most of that to improved treatments.Overseeing this change at the Food and Drug Administration has been Dr. Richard Pazdur, currently the director of the Oncology Center of Excellence. Trained as an oncologist, he leads the agency and its cancer specialists in determining how cancer drugs are tested and approved.Through 25 years at the agency in a variety of roles, he has been present from the start of the new era and has seen firsthand how scientific discoveries completely changed the prospects for many cancer patients. In two edited and condensed conversations, he discussed what he has seen, and what he hopes for.What was it like to be a cancer doctor when you first began, and what has changed?When I started in medical oncology in 1979, we had less than 40 oncology drugs for all cancers. I came to the F.D.A. in 1999, thinking that most drug development would be done by the National Cancer Institute. I thought industry would have very little interest because most drugs were short course with excessive toxicity and many patients had a poor prognosis.I couldn\u2019t have been more wrong. For many patients, things have changed dramatically. From 1999 until the present, we approved 201 cancer drugs. When I came to the F.D.A. there were about 10 medical oncologists at the agency. Now there are 100.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0log into\u00a0your Times account, or\u00a0subscribe\u00a0for all of The Times.Thank you for your patience while we verify access.Already a subscriber?\u00a0Log in.Want all of The Times?\u00a0Subscribe.<\/p>\n","protected":false},"author":1,"featured_media":16184,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-16182","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/16182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16182"}],"version-history":[{"count":2,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/16182\/revisions"}],"predecessor-version":[{"id":16185,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/16182\/revisions\/16185"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/16184"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}