{"id":11187,"date":"2024-08-13T09:01:21","date_gmt":"2024-08-13T09:01:21","guid":{"rendered":"https:\/\/medexperts.pro\/?p=11187"},"modified":"2024-08-13T09:26:04","modified_gmt":"2024-08-13T09:26:04","slug":"hot-summer-threatens-efficacy-of-mail-order-medications","status":"publish","type":"post","link":"https:\/\/medexperts.pro\/?p=11187","title":{"rendered":"Hot Summer Threatens Efficacy of Mail-Order Medications"},"content":{"rendered":"<div><\/div>\n<p id=\"article-summary\" class=\"css-79rysd e1wiw3jv0\">The temperatures inside delivery trucks can reach twice the recommended threshold, but federal rules on drug storage conditions do not apply to the booming world of mail-order delivery.<\/p>\n<section class=\"meteredContent css-1r7ky0e\">\n<div class=\"css-s99gbd StoryBodyCompanionColumn\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Melted capsules. Cloudy insulin. Pills that may no longer work.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Doctors and pharmacists say the scorching temperatures enveloping the country could be endangering people\u2019s health in an unexpected way: by overheating their medications.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Millions of Americans now receive their prescription medications through mail-order shipments, either for convenience or because their health plans require it. But the <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2022\/08\/20\/business\/ups-postal-workers-heat-stroke-deaths.html\" title>temperatures inside the cargo areas of delivery trucks<\/a> can reach 150 degrees Fahrenheit in the summer, <a class=\"css-yywogo\" href=\"https:\/\/twitter.com\/TeamsterRnF\/status\/1554580088452268036?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1554580088452268036%7Ctwgr%5E41a7db4772f8466f7eff174671214f7ba721f074%7Ctwcon%5Es1_&amp;ref_url=https%3A%2F%2Fwww.theguardian.com%2Fus-news%2F2022%2Faug%2F03%2Fups-drivers-trucks-heat-temperatures\" title rel=\"noopener noreferrer\" target=\"_blank\">according to drivers<\/a> \u2014 far exceeding the range of 68 to 77 degrees recommended by the national organization that sets standards for drug handling.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Mail-order pharmacies say that their packaging is <a class=\"css-yywogo\" href=\"https:\/\/www.express-scripts.com\/frequently-asked-questions\/home-delivery\" title rel=\"noopener noreferrer\" target=\"_blank\">weather resistant<\/a> and that they take special precautions when medication \u201crequires specific temperature control.\u201d But in a study published last year, independent pharmaceutical researchers who embedded data-logging thermometers inside simulated shipments found that the packages had spent <a class=\"css-yywogo\" href=\"https:\/\/www.japha.org\/action\/showPdf?pii=S1544-3191%2823%2900018-3\" title rel=\"noopener noreferrer\" target=\"_blank\">more than two-thirds<\/a> of their transit time outside the appropriate temperature range, \u201cregardless of the shipping method, carrier, or season.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Extreme temperatures can alter the components in many medications, from pancreatic enzymes to the thyroid replacement drug <a class=\"css-yywogo\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5502408\/\" title rel=\"noopener noreferrer\" target=\"_blank\">levothyroxine<\/a> to oral contraceptives, medical experts say.<\/p>\n<p class=\"css-at9mc1 evys1bk0\"><a class=\"css-yywogo\" href=\"https:\/\/www.bcm.edu\/people-search\/xinqi-mike-ren-29327\" title rel=\"noopener noreferrer\" target=\"_blank\">Dr. Mike Ren<\/a>, a primary care physician and an assistant professor in the department of family and community medicine at the Baylor College of Medicine, said that liquid medications like <a class=\"css-yywogo\" href=\"https:\/\/www.health.harvard.edu\/blog\/safe-and-effective-use-of-insulin-requires-proper-storage-2018120415486\" title rel=\"noopener noreferrer\" target=\"_blank\">insulin<\/a> or AUVI-Q, the epinephrine injection for allergic reactions, are often at heightened risk of degradation because excessive heat exposure can cause the evaporation of liquid components that were compounded at precise ratios. Aerosolized medications, too, are uniquely vulnerable because of the risk of pressure changes in the canister.<\/p>\n<\/div>\n<\/div>\n<div>\n<div data-testid=\"imageblock-wrapper\">\n<figure class=\"img-sz-large css-bkbwf1 e1g7ppur0\" aria-label=\"media\" role=\"group\">\n<div class=\"css-1xdhyk6 erfvjey0\" data-testid=\"photoviewer-children-figure\">\n<div class=\"css-nwd8t8\" data-testid=\"lazy-image\">\n<div data-testid=\"lazyimage-container\" style=\"height:257.77777777777777px\"><\/div>\n<\/div>\n<\/div><figcaption data-testid=\"photoviewer-children-caption\" class=\"css-1g9ic6e ewdxa0s0\"><span class=\"css-jevhma e13ogyst0\">A summertime delivery route in Brooklyn. Temperatures inside the cargo areas of delivery trucks can reach 150 degrees Fahrenheit in the summer, according to drivers.<br \/><\/span><span class=\"css-1u46b97 e1z0qqy90\"><span><span aria-hidden=\"false\">Johnny Milano for The New York Times<\/span><\/span><\/span><\/figcaption><\/figure>\n<\/div>\n<\/div>\n<div>\n<div class=\"css-1336jj\">\n<div class=\"css-121kum4\">\n<div class=\"css-171d1bw\"><\/div>\n<div class=\"css-asuuk5\">\n<div class=\"css-7axq9l\" data-testid=\"optimistic-truncator-noscript\">\n<div data-testid=\"optimistic-truncator-noscript-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">We are having trouble retrieving the article content.<\/p>\n<p class=\"css-3kpklk\">Please enable JavaScript in your browser settings.<\/p>\n<\/div>\n<\/div>\n<div class=\"css-1dv1kvn\" id=\"optimistic-truncator-a11y\">\n<hr \/>\n<p>Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0<a href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F08%2F13%2Fhealth%2Fheat-mail-order-drugs.html&amp;asset=opttrunc\">log into<\/a>\u00a0your Times account, or\u00a0<a href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F08%2F13%2Fhealth%2Fheat-mail-order-drugs.html\">subscribe<\/a>\u00a0for all of The Times.<\/p>\n<hr \/>\n<\/div>\n<div class=\"css-1g71tqy\">\n<div data-testid=\"optimistic-truncator-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">Thank you for your patience while we verify access.<\/p>\n<p class=\"css-3kpklk\">Already a subscriber?\u00a0<a data-testid=\"log-in-link\" class=\"css-z5ryv4\" href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F08%2F13%2Fhealth%2Fheat-mail-order-drugs.html&amp;asset=opttrunc\">Log in<\/a>.<\/p>\n<p class=\"css-3kpklk\">Want all of The Times?\u00a0<a data-testid=\"subscribe-link\" class=\"css-z5ryv4\" href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F08%2F13%2Fhealth%2Fheat-mail-order-drugs.html\">Subscribe<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>The temperatures inside delivery trucks can reach twice the recommended threshold, but federal rules on drug storage conditions do not apply to the booming world of mail-order delivery.Melted capsules. Cloudy insulin. Pills that may no longer work.Doctors and pharmacists say the scorching temperatures enveloping the country could be endangering people\u2019s health in an unexpected way: by overheating their medications.Millions of Americans now receive their prescription medications through mail-order shipments, either for convenience or because their health plans require it. But the temperatures inside the cargo areas of delivery trucks can reach 150 degrees Fahrenheit in the summer, according to drivers \u2014 far exceeding the range of 68 to 77 degrees recommended by the national organization that sets standards for drug handling.Mail-order pharmacies say that their packaging is weather resistant and that they take special precautions when medication \u201crequires specific temperature control.\u201d But in a study published last year, independent pharmaceutical researchers who embedded data-logging thermometers inside simulated shipments found that the packages had spent more than two-thirds of their transit time outside the appropriate temperature range, \u201cregardless of the shipping method, carrier, or season.\u201dExtreme temperatures can alter the components in many medications, from pancreatic enzymes to the thyroid replacement drug levothyroxine to oral contraceptives, medical experts say.Dr. Mike Ren, a primary care physician and an assistant professor in the department of family and community medicine at the Baylor College of Medicine, said that liquid medications like insulin or AUVI-Q, the epinephrine injection for allergic reactions, are often at heightened risk of degradation because excessive heat exposure can cause the evaporation of liquid components that were compounded at precise ratios. Aerosolized medications, too, are uniquely vulnerable because of the risk of pressure changes in the canister.A summertime delivery route in Brooklyn. Temperatures inside the cargo areas of delivery trucks can reach 150 degrees Fahrenheit in the summer, according to drivers.Johnny Milano for The New York TimesWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0log into\u00a0your Times account, or\u00a0subscribe\u00a0for all of The Times.Thank you for your patience while we verify access.Already a subscriber?\u00a0Log in.Want all of The Times?\u00a0Subscribe.<\/p>\n","protected":false},"author":1,"featured_media":11189,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-11187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lifestyle"],"_links":{"self":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/11187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11187"}],"version-history":[{"count":2,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/11187\/revisions"}],"predecessor-version":[{"id":11190,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/posts\/11187\/revisions\/11190"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=\/wp\/v2\/media\/11189"}],"wp:attachment":[{"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medexperts.pro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}