The two solvents, known as Perc and TCE, cause kidney cancer and other ailments, and have been the subject of years of controversy.

The Environmental Protection Agency on Monday banned two solvents found in everyday products that can cause cancer and other serious diseases. It was a move long sought by environmental and health advocates, even as they braced for what could be a wave of deregulation by the incoming Trump administration.

For decades, communities close to factories, airports, dry cleaners and other sites have lived with the consequences of exposure to trichloroethylene, or TCE, a toxic chemical used in cleaners, spot removers, lubricants and glue.

TCE is known to cause liver cancer, kidney cancer and non-Hodgkin’s lymphoma, and to damage the nervous and immune systems. It has been found in drinking water nationwide and was the subject of a 1995 book that became a movie, “A Civil Action,” starring John Travolta. The E.P.A. is banning all uses of the chemical under the Toxic Substances Control Act, which was overhauled in 2016 to give the agency greater authority to regulate harmful chemicals.

The E.P.A. also banned all consumer uses of perchloroethylene, used in dry-cleaning and in automotive-care products. Though it is less harmful than TCE, the solvent, also called Perc, can cause liver, kidney, brain and testicular cancer, and can damage kidneys, the liver and the immune system.

The E.P.A.’s ban of Perc still allows for a range of industrial uses, including in aviation and defense, with the provision that strict rules must be in place to protect workers. Both bans were initially proposed in 2023.

“It’s simply unacceptable to continue to allow cancer-causing chemicals to be used for things like glue, dry cleaning or stain removers when safer alternatives exist,” said Michal Freedhoff, assistant administrator for the E.P.A. Office of Chemical Safety and Pollution Prevention.

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